It has the sixth-highest incidence among all cancers and is the third leading cause of cancer-related death globally 2 - 4. Serum C-reactive protein is a useful biomarker for predicting outcomes after liver transplantation in patients with hepatocellular carcinoma. Epub 2012 Nov 13. 10, (No. Hepatocellular carcinoma (HCC) as a kind of malignant tumor that leads to very high morbidity and mortality around the world, especially in China. Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of the leading causes of cancer-related death worldwide. The transcription factor forkhead box O3 (FOXO3) has been related to hepatic diseases and tumor. DNA methylation: potential biomarker in Hepatocellular Carcinoma Way-Champ Mah1,2,3 and Caroline GL Lee1,2,3,4* Abstract Hepatocellular Carcinoma (HCC) is one of the most common cancers in the world and it is often associated with poor prognosis. 1-3 Hepatocellular carcinoma (HCC) is the majority type of liver cancer. Yao R, Zou H, Liao W. Prospect of Circular RNA in Hepatocellular Carcinoma: A Novel Potential Biomarker and Therapeutic Target. HCC is highly heterogeneous, both within the tumor and among . Free Online Library: Long Noncoding RNAs Act as Novel Biomarkers for Hepatocellular Carcinoma: Progress and Prospects. Hepatocellular carcinoma (HCC) is a highly malignant tumor found in the bile duct epithelial cells, and the second most common tumor of the liver. Song X, Wu A, Ding Z, Liang S, Zhang C: Soluble Axl is a novel diagnostic biomarker of hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection. The identification of novel, highly specific and more sensitive biomarkers for HCC is crucial because existing ones are deficient and non-confirmatory without histological biopsy or imaging techniques. 2010;26(3):425-433. Liver Transpl, (12):1406-1414 2012 MED: 22821639 3), pp: 383-394 Research Paper Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma Devis Pascut1,*, Caecilia Hapsari Ceriapuri Sukowati1,2,*, Giulia Antoniali2, Giovanna Mangiapane2, Silvia Burra2, Luca Giovanni Mascaretti4, Matteo Rossano Buonocore3, Lory Saveria Crocè3,5,1, Claudio Tiribelli1 and Gianluca Tell2 1 . www.oncotarget.com Oncotarget, 2019, Vol. Diagnosis: Novel prognostic biomarkers in hepatocellular carcinoma. This review provides details on novel potentially vulnerable targets in the oncogenic signaling pathways associated with HCC development and progression, which should be . Recent studies have shown that circulating microRNAs are a potential biomarker in various types of malignancies. Accurate detection and differential diagnosis of early HCC can significantly improve patient survival. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. The expression levels of 24 . The primary cause is the low efficacy of current therapeutic regimens available to treat advanced HCC. Alternative splicing (AS) is a transcriptional regulation mechanism that participates in multiple aspects of cancer. This article aims to review the recent evidence based on HCC biomarkers which seems to have a regulative role according to tumor cell development leading to a specific biological response. Chronic hepatitis B virus (HBV) infection is a known major etiological factor for hepatocellular carcinoma (HCC) development. This study aimed to identify serum biomarkers for microvascular invasion (MVI) in hepatocellular carcinoma (HCC). Aim: To validate a novel Japanese indication criteria for liver transplantation (LT) for hepatocellular carcinoma (HCC), i.e., the 5-5-500 criteria (nodule size ≤ 5 cm in diameter, nodule number ≤ 5, and alfa-fetoprotein (AFP) value ≤ 500 ng/mL) and the Japanese double eligibility criteria (DEC) (patients meeting the Milan or the 5-5-500 criteria) in the University of Tokyo cohort. Hepatocellular carcinoma (HCC) is a highly malignant cancer which lack of effective diagnosis and prognosis biomarkers, therefore surging studies focused on the metabolite candidates for HCC. The serum of HCC patients with different vascular invasion statuses was examined by iTRAQ-based proteomic profiling. Although factors, including alcoholic abuse, fatty liver and aflatoxin, could induce the carcinogenesis of HCC, 4 hepatic B virus . 2013, Article ID 136106, 5 pages, 2013. Hepatocellular carcinoma (HCC) is one of the main cancer-related causes of death worldwide. The HCC diagnosis is usually achieved by biomarkers, which can also help in prognosis prediction. The aim of this study was to investigate the feasibility of using serum exosomal. Therefore, we present a further study on CFHR3 in HCC. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in the world owing to limitations in its prognosis. Kim SU, Park JH, Kim HS, et al. The current study was designed to systematically review the metabolic studies for HCC, summarize the current available evidence and provide implication . Cancer Res Treat. 22. However, the pivotal roles of most molecules of tumorigenesis in HCC are still unclear. Although new and advanced treatments have emerged in recent years, the survival rate of liver cancer is still very low, and the prognosis is very poor . MVI is a histological sign of micrometastasis in the liver and is considered as one of the most powerful prognostic factors in HCC. Authors Roberta W C Pang, . Recently, circulating microRNAs (miRNAs) have been reported to be promising biomarkers for diagnosing and monitoring cancers. In spite of the numerous efforts to find molecules as possible biomarkers, there is not a single ideal marker in HCC. Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related mortality (~800,000 deaths/year). Currently, detection of HCC in clinical practice is performed by diagnostic imaging techniques and determination of serum biomarkers, most notably α-fetoprotein (AFP . Biomarkers represent a relatively easy and noninvasive way to detect and estimate disease prognosis. Therefore, we sought . 10.4143/crt.2019.749 Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma. Identi cation of Novel Potential Biomarkers in Hepatocarcinoma Cancer; A Transcriptome Analysis Mohib kakar ( [email protected] ) Beijing Institute of Technology Muhammad Mehboob CAS Centre for Excellence in Biotic Interaction, College of Life Sciences, University of Chinese Academy of Science, Beijing, 100049, China Muhammad Akram Institute for Synthetic Biosystem, School of Chemistry . Core tip: Hepatocellular carcinoma (HCC) remains a critical concern worldwide due to the severity of disease outcome. Liver transplantation and resection are two currently available curative therapies. In spite of the numerous efforts to find molecules as possible biomarkers, there is not a single ideal marker in HCC. The performance of the novel biomarker panels was similar to the GALAD score. Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. Therefore, better biomarkers are needed to determine the specific prognosis and progression of HCC. Circulating miRNAs as novel diagnostic biomarkers in hepatocellular carcinoma detection: a meta-analysis based on 24 articles The diagnostic value and suitability of circulating miRNAs for the detection of hepatocellular carcinoma have been inconsistent in the literature. Many new findings have shown promising results both in diagnosing and treating HCC. The low rate of early diagnosis, as well as the high risk of postoperative metastasis and recurrence, led to the poor clinical prognosis of HCC patients. This 70 kD glycoprotein is produced by the fetal liver and yolk sac during the first trimester of pregnancy and declines rapidly after birth [ 28 ]. Novel biomarkers in hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. However, its prognostic values of CFHR3 in hepatocellular carcinoma (HCC) are not understandable. Etiologic Factors of HCC Therefore, the identification and development of sensitivity- genes as novel diagnostic markers and effective therapeutic targets is urgently needed. In CHB patients, a decrease in HBcrAg is associated with favorable outcomes. Dopamine and dopamine receptor D1 (DRD1) are reported to be involved in the progression of various cancers. A Novel Prognostic Biomarker LPAR6 in Hepatocellular Carcinoma via Associating with Immune Infiltrates Jian He*, Mei Meng and Hui Wang* State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China It reflects vitamin D obtained from food and supplements and has a fairly long circulating half-life of 15 days. Diagnosis: Novel prognostic biomarkers in hepatocellular carcinoma Nat Rev Gastroenterol Hepatol. Homer2 and Homer3 Act as Novel Biomarkers in Diagnosis of hepatitis B virus-induced Hepatocellular Carcinoma Introduction. Most of these patients are seen with advanced disease at the time of presentation. Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality and poor prognosis in the world. Two multitarget tyrosine kinase inhibitors (TKI), lenvatinib and sorafenib, are used as standard-of-care chemotherapeutics in patients with advanced HCC, but a stratification strategy has not been established because of a lack of efficacious biomarkers. Thus, there is a constant search for improvement in screening, diagnosis, and treatment strategies to improve the prognosis of this malignancy. Among these, immune checkpoint inhibitors (ICIs) have been widely evaluated and are under assessment, as monotherapy or in combination with other anticancer agents in . An HJ, Jang JW, Bae SH, Choi JY, Yoon SK, Lee MA, You YK, Kim DG, Jung ES. The current prognosis approaches include radiological examination and detection of serum biomarkers, however, both have limited efficiency and are ineffective in early prognosis. Hepatocellular carcinoma (HCC) is characterized by high intertumor heterogeneity of genetic drivers. Invasive and noninvasive assessment of hepatocellular carcinoma (HCC). Background: NEDD1 (NEDD1 Gamma-Tubulin Ring Complex Targeting Factor) plays a crucial impact in regulating cell cycle and the development of scirrhous gastric cancer. Alpha-fetoprotein (AFP) is the most commonly used biomarker for HCC surveillance. Most of these patients are seen with advanced disease at the time of presentation. Hepatocellular carcinoma (HCC) represents one of the main causes of cancer-related death worldwide. In this review, we summarize current HCC biomarker studies, highlighting novel biomarkers and imaging tests that may improve surveillance and diagnosis of HCC in the future (Figure 1). The identification of useful biomarkers for surveillance and early HCC diagnosis is still deficient, with available serum biomarkers showing low sensitivity and . The aim was to develop and validate a biomarker-based model for predicting sorafenib response and overall survival (OS). The diagnosis of HCC without pathologic confirmation is achieved by analyzing serum alpha-fetoprotein (AFP) levels combined with imaging techniques, including ultrasonography . Over the next few years, novel systemic treatment options have emerged. 25(OH)D levels do not indicate the amount of vitamin D stored in body tissues. Int J Mol Med. This study aimed to identify serum biomarkers for microvascular invasion (MVI) in hepatocellular carcinoma (HCC). Figure 1. In spite of its high prevalence, there are not many therapeutic options available for patients with advanced-stage HCC. (Report, Author abstract) by "BioMed Research International"; Biotechnology industry High technology industry Biological markers Comparative analysis Health aspects Methods Cancer Cancer research Hepatocellular carcinoma Development and progression Diagnosis Hepatoma Liver . Hepatocellular Carcinoma (HCC) is the sixth most common cancer and the third cancer-related cause of death, with more than 800,000-related deaths each year. AFP is structurally very similar to albumin, with just a modification in an N terminal sequence. Methods Candidate ctDNA biomarkers was prescreened in urine samples obtained . Homer2 and Homer3 Act as Novel Biomarkers in Diagnosis of hepatitis B virus-induced Hepatocellular Carcinoma Ping Luo,1,6,*Chunzi Liang,6,*Wei Jing,2Man Zhu,3Hu Zhou,4Hongyan Chai,6Paul F. Worley,5and Jiancheng Tu6, Ping Luo 1Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China. Alpha-fetoprotein (AFP) is widely used to detect primary HCC, whereas its sensitivity and specificity are not satisfying. Hepatocellular carcinoma (HCC) is one of the most important malignant tumors of the liver. However, most 2018;8:332. Google Scholar 1 1 Urine biomarker: novel approach to hepatocellular carcinoma screening Short title: Hepatocellular carcinoma screening in urine Amy K Kim1*, James P. Hamilton1*, Selena Y. Lin2, Ting-Tsung Chang3, Hie-Won Hann4, Chi-Tan Hu5, Yue Lou6, Yih-Jyh Lin7, Terence P. Gade8 Grace Park4, Harry Luu1, Tai-Jung Lee6, Jeremy Wang2, Dion Chen9, Michael G. Goggins1,10, Surbhi Jain2, The 5-year overall survival rate after radical resection is about 15-40% and within . Background: Serum concentration of 25-hydroxy vitamin D (25(OH) D) is the major circulating form of vitamin D and the best indicator of assessment of vitamin D status. 2020;3565:31224-6. 1. Deep RNA sequencing of three paired hepatocellular carcinoma (HCC) tumors and adjacent non . The primary cause is the low efficacy of current therapeutic regimens available to treat advanced HCC. Abstract. Recent studies have shown that circulating microRNAs are potential biomarkers for various types of malignancies. hepatocellular carcinoma: towards novel molecular biomarkers Camille Martenon Brodeur1, Philippe Thibault 2, Mathieu Durand, Jean-Pierre Perreault1 and Martin Bisaillon1 1 Département de biochimie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada Blood Sample Collection to Evaluate Biomarkers for Hepatocellular Carcinoma Jacksonville, FL The purpose of this study is to obtain de-identified, clinically-characterized whole blood specimens for use in developing and evaluating the performance of new biomarker assays for detection of hepatocellular carcinoma (HCC). Shigemune Bekki, Satoru Hashimoto, Kazumi Yamasaki, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Akira Saeki, Tomoyuki Suehiro, Yuki Kugiyama, Asami Beppu Introduction. The expression levels of 24 . Complement factor H-related 3 (CFHR3) is a protein-coding gene acting in various diseases. Hepatocellular carcinoma (HCC) is the seventh most common cancer diagnosis worldwide with high associated mortality ().HCC is a unique malignancy, as it typically arises in the setting of chronic liver disease in particular cirrhosis, with competing risks of liver failure, contributing to its low 5-year survival rates of 18%-20% ().More than half of worldwide HCC-related deaths occur in Asia . Due to such limitations, we propose to use RNA-Seq data for evaluating putative higher . 4. Downregulation of CYP39A1 Serves as a Novel Biomarker in Hepatocellular Carcinoma with Worse Clinical Outcome December 2021 Oxidative Medicine and Cellular Longevity 2021(14):1-18 Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation. This prospective cohort study included 124 consecutive HCC patients (44 with disease control, 80 with progression) with Child . identification of biomarkers for diagnosis at an early stage may result in significant benefits. Novel Altered Region for Biomarker Discovery in Hepatocellular Carcinoma (HCC) Using Whole Genome SNP Array Novel cytogenetic aberration for hepatocellular carcinoma Esraa M. Hashem1 1Biomedical Engineering Department Misr University for Science and Technology (MUST University) Cairo, Egypt Mai S. Mabrouk2* 2Biomedical Engineering Department Hepatocellular carcinoma (HCC), which is closely related to chronic liver disease, accounts for most primary liver cancers (representing 70 to 85%) 1. J Cancer 2021; 12(12):3439-3447. doi:10.7150/jca.52118 This issue. Huang et at. 2012 Dec;9(12):691-2. doi: 10.1038/nrgastro.2012.208. Hepatocellular carcinoma (HCC) is one of the main cancer-related causes of death worldwide. Furthermore, it might represent certain therapeutic interventions through some combinations of biomarkers. 2. Clin Gastroenterol Hepatol. Serum Dickkopf-1 as a biomarker for the diagnosis of hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. Background & Aims Continued limitations in hepatocellular carcinoma (HCC) screening have led to late diagnosis with poor survival, despite well-defined high-risk patient populations. The expression level of NEDD1 was negatively correlated to the prognosis of H CC patients and it may be a promising therapeutic target of HCC, which probably be able to predict the efficacy of immunotherapy for HCC patients. Prediction of the outcome of sorafenib therapy using biomarkers is an unmet clinical need in patients with advanced hepatocellular carcinoma (HCC). A novel blood-based panel of methylated DNA and protein markers for detection of early-stage hepatocellular carcinoma. The 5-year survival rate of HCC is only approximately 15% 5, 6. Introduction. Hepatocellular carcinoma (HCC) is a common cancer, and the second most common cause of cancer-associated death globally. The average survival in untreated HCC patients is estimated to be approximately three months. The aim of this study was to investigate the feasibility of using serum exosomal microRNAs (miRNAs) as novel serological biomarkers for hepatocellular carcinoma (HCC) diagnosis and prognosis. Hepatocellular carcinoma (HCC) is a common form of liver cancer associated with high mortality rate [].It is estimated that approximately 750,000 new cases of HCC diagnosed per year worldwide which makes HCC as the fifth common cause of cancers affecting human [].Mortality rate of approximately 700,000 has been estimated annually due to HCC and it has been considered as the . 1 First-line conventional therapies, such as chemotherapy, radiotherapy and surgery, have demonstrated limited results, and the prognosis of patients remains quite poor. Core tip: Hepatocellular carcinoma (HCC) remains a critical concern worldwide due to the severity of disease outcome. In such a complicated scenario, tools for early diagnosis and prognosis prediction are fundamental for patient stratification. Novel serological biomarkers reflect intrahepatic viral replicative activity or the progression of liver fibrosis, indicating non-invasive alternatives to liver biopsy: (1) Hepatitis B core-related antigen (HBcrAg) correlates with serum HBV DNA and intrahepatic cccDNA. Beppu T, Sugimoto K, Shiraki K, et al. One of the major reasons for this high rate of mortality is a failure to make an early diagnosis. . www.oncotarget.com Oncotarget, 2019, Vol. Liver cancer is one of the most commonly occurring tumours around the world, especially in epidemic areas of hepatic viruses, such as Japan, South Korea, China and Thailand. Hepatocellular carcinoma (HCC) is the most common liver malignancy and a leading cause of cancer-related mortality worldwide. Research Paper. recently described a comparative analysis looking at differential . Using serum exosomal the next few years, novel systemic treatment options emerged! 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